research
- Dan, Tobin, Kyle Kyburz, and undergraduate researcher Emi Kiyotake report on a photodegradable hydrogel for the co-culture of motor neurons and muscle cells. Confocal microscopy is used to erode three-dimensional channels allowing directed
Malar, Dan, and Danny show the gelation and degradation kinetics of a polymer network using coumarin as a new class of photodegradable crosslink. Micron-scale erosion was performed at wavelengths as long as 860 nm. Find the paper
Samir Singh showed scaffold modulus and peptide functionalization affected tumor cell migration in a 3D synthetic matrix. His paper, entitled "A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of
Daniel McKinnon and Dylan Domaille (postdoc in Jen Cha's lab) "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies" in Chemistry of
Chun Yang publishes "Mechanical memory and dosing influence stem cell fate" in Nature Materials. She shows that hMSCs differentiate differently when exposed to surfaces of different moduli for different periods of time. Congratulations Chun!
Emi Tokuda and Jen Leight published "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness" in Biomaterials showing the synergistic effect of matrix mechanics and melonoma drugs on cell response.E.Y. Tokuda, J.L.
Nava showed the ability to reversibly exchange biochemical ligands using allyl sulfide-based living click strategies. Congratulations Nava!N.R. Gandavarapu, M.A. Azagarsamy, and K.S. Anseth, "Photo-Click Living Strategy for Controlled,- Daniel McKinnon publishes "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems" in Advanced Materials. He developed a cytocompatible covalently adaptable hydrogel that enabled cell
- Danny Alge and his undergraduate researcher Dylan Donohue characterized the addition of a lewis acid catalyst (nickel) in the synthesis of a tetrazine molecule useful in click chemistry applications.D.L. Alge, D.F. Donohue, and K
- Sharon Wang showed the unique gene expression profiles of several valvular interstitial subtypes. Her work will have deep impact in the heart disease community and showed that a certain subpopulation of cells participates in tissue repair and