research
In this paper, former undergraduate research Michael Nehls and postdoc Adrianne Rosales demonstrate control over release kinetics of a model peptide drug based on a photo-switchable host/guest interaction between azobenzene and cyclodextrin. Check- This excellent review summarizes many of the techniques used to make reversible hydrogels. Whether the reversibility is in the crosslinks themselves, or in pendant functional groups, these gels have many interesting and exciting properties.
In this paper, the authors describe a hydrazone crosslinked hydrogel formed by the reaction of photo-generated aldehydes with pendant hydrazine functionalities. The same reaction is also used to pattern biochemical ligands within the gel. Check- In her latest publication, recent PhD graduate Kelly Mabry analyzes the differences in gene expression between freshly isolated valvular interstitial cells (VICs) and those cultured on conventional tissue culture plastic, on two-dimensional
- Noteworthy Chemistry, a weekly publication by the ACS that highlights specific articles from a broad range of literature, selected two of our articles for their feature. Photocontrolled Nanoparticles for On-Demand Release of Proteins was
- In this work, Kelly investigates the effect of dynamic hydrogel stiffening on encapsulated VICs. Check out the article (appearing in the journal Biomaterials) here.
- In this work, Jen (now at Ohio State) and Emi (now at Seattle Children's Hospital) investigate the effect of cancer drugs on matrix metalloproteinase (MMP) and metabolic activity of melanoma cells at various stages of metastasis. Their findings
In this work, Katie uses photodegradable hydrogel microparticles to create three dimensional cyst-like structures to mimic the native alveoli of the lung epithelium. Check out the article here!
In this paper, Balaji Sridhar demonstrates improved glycosaminoglycan and collagen deposition by co-encapsulating chondrocytes and MSCs in a functionalized cell-degradable PEG hydrogel. Check it out here!
This article, detailing a method for measuring the force of extending neurites, was recently accepted to Soft Matter and also invited for a cover art submission. An advance version is available here.