Xiaoyun Ding
Associate Professor • Bruce S. Anderson Faculty Fellow • Biomedical, Micro/Nanoscale, Thermo Fluid Sciences

Office Location: ECES 158
Lab Location: ECES 117

Research Interests

Biomedical microfluidics, intracellular delivery, drug delivery, lab on chip, cellular engineering

Xiaoyun Ding’s research group centers on the innovation of cutting-edge micro/nano systems for cell based biomedical applications, including micro/nano manipulation of cell and fluid, cell membrane disruption and repair, and precise intracellular/subcellular delivery. Our research is highly interdisciplinary at the frontiers of micro/nano engineering, biomedical engineering, acoustics, electronics, and other applied physics.

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Societal Impact

We strive to improve human health and life quality through innovations in engineering cell functions for cell-based immunotherapy and reducing costs of disease diagnostics and therapeutics.

Select Publications

  • Gazendra Shakya, Tao Yang, Yu Gao, Apresio K. Fajrial, Baowen Li, Massimo Ruzzene, Mark A. Borden, and Xiaoyun Ding. Manipulating Internal Structure of Endoskeletal Droplets using Acoustic Waves.ÌýNature Communication, 13 (1), 1-9, (2022).
  • Yu Gao, Apresio K Fajrial, Tao Yang, Xiaoyun Ding. Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization,ÌýBiomaterials Science,Ìý9.5: 1574-1582. (2021). (BackÌýcover story)Ìý
  • Apresio K. Fajrial, Kun Liu, Yu Gao, Junhao Gu, Richard Lakerveld, and Xiaoyun Ding. Characterization of single-cell osmotic swelling dynamics for new physical biomarkers,ÌýAnalytical Chemistry, 2020. (Front cover story)
  • Apresio Kefin Fajrial, Qing Qing He, Nurul I. Wirusanti, Jill Slansky, and Xiaoyun Ding. A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing.ÌýTheranostics, 10(12):5532-5549. (2020).
  • Yonghui Ding, Kerri A. Ball, Kristofor J. Webb, Yu Gao, Angelo D’Alessandro, William M. Old, Michael H.B. Stowell, Xiaoyun Ding. On-chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability,ÌýSmall, 2003506, 2020. (Front Cover Story)
  • Gazendra Shakya, Samuel E. Hoff, Shiyi Wang, Hendrik Heinz, Xiaoyun Ding and Mark A. Borden. Vaporizable endoskeletal droplets via tunable interfacial melting transitions.ÌýScience AdvancesÌý6.14: eaaz7188,Ìý(2020).
  • Apresio Fajrial, Xiaoyun Ding, Advanced Nanostructures for Cell Membrane Poration.ÌýNanotechnology, 30, 264002, (2019)
  • Xiaoyun Ding, Martin Stewart, Armon Sharei, James Weaver, Robert Langer, and Klavs Jensen,ÌýNature Biomedical Engineering, 1, 0039 (2017)
  • Martin P Stewart, Armon Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer, Klavs F Jensen,ÌýÌýNatureÌý538 (7624), 183-192 (2016)
  • Xiaoyun Ding,Ìýet al.,ÌýProceedings of the National Academy of Sciences of the United States of America (PNAS),Ìý111, 12992-12997 (2014).
  • Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 13, 3626-3649 (2013).
  • Xiaoyun Ding,Ìýet al.,ÌýProceedings of the National Academy of Sciences of the United States of America (PNAS),Ìý109, 11105-11109 (2012).
  • Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 12, 4228–4231 (2012). (Cover Image)
  • Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 12, 2491-2497 (2012). (Cover image)

Select Awards

  • 2022Ìý The Penn State Graduate School Alumni Society Early Career Award (1 awardee worldwide yearly)
  • 2021Ìý NIH MIRA Early Stage Investigator AwardÌý
  • 2021Ìý Bruce S. Anderson Engineering Faculty Fellow, University of ÃÛÌÇÖ±²¥Ìý
  • 2020Ìý Lab Venture Challenge 2020 winner, ÃÛÌÇÖ±²¥Ìý
  • 2020Ìý Biomaterials Science Emerging Investigators 2021
  • 2019Ìý W. M. Keck Foundation Medical Research Grant Award
  • 2019Ìý CCTSI Novel Method Development Pilot Awards, ÃÛÌÇÖ±²¥
  • 2013Ìý Rustum and Della Roy Innovation in Materials Research Award, The Penn State University
  • 2013Ìý Inventor Incentive Award, The Penn State University
  • 2013Ìý Journal of Laboratory Automation Ten Breakthroughs in Innovation Award (JALA Ten 2013)
  • 2012 ÌýStudent Paper Competition Award, IEEE International Ultrasonics Symposium, Dresden, GermanyÌý
  • 2012 ÌýThe Baxter Young Investigator Award, Chicago, USA (6 awardees nationwide)
  • 2012 ÌýFirst Place Award at Penn State ESM Today Graduate Research Symposium, The Penn State University
  • 2011 ÌýInnovation Award at Penn State ESM Today Graduate Research Symposium, ÌýThe Penn State University

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