Transcription regulation by molecular condensates
Understanding the mechanisms that control RNA Polymerase II (Pol II) transcription are essential to gain insight about human development and disease.ÌýÌýOne phenomenon that may modulate transcription is liquid-liquid phase separation (LLPS). LLPS drives the formation of molecular condensates at regions that contain a high density of transcription factors and nucleic acids.ÌýÌýMy projects focus on how phase separation affects Pol II activity and its regulation by other transcription-associated proteins. The goal is to determine the mechanisms by which molecular condensates might influence transcriptional output and how condensates may function at distinct regions in the human genome.Ìý
Publications
Palacio, M; Taatjes DJ.ÌýÌýJ Mol BiolÌý2022, 433: 167216.
Rudolph, J; Muthurajan, UM; Palacio, M; Mahadevan, J; Roberts, G; Erbse, AH; Dyer, P; Luger, K. Mol Cell 2021, 81: 4994 - 5006.Ìý