Multi-program PhD candidate first author on cardiac fibrosis-based paper
Cierra Walker, a PhD candidate in the both the Materials Science and Engineering Program and Interdisciplinary Quantitative Biology Program at 蜜糖直播 Boulder is the first author on a new paper in Nature that explores what happens to cells after a heart attack.
Titled and appearing in Nature Biomedical Engineering, Walker said the paper will help doctors and researchers better understand and treat damage after cardiac fibrosis develops.
鈥淎fter a heart attack, your heart cells gets stiffer. This is known as cardiac fibrosis and it reduces the heart鈥檚 ability to function properly,鈥 she said. 鈥淔ibrosis impacts the cell operation within your heart, causing the cells to further promote fibrosis progression or 鈥榓ctivation.鈥 So a major goal for doctors and researchers is to reverse the cell's activation and help the cells return to normal.鈥
Walker added that 鈥 in the paper 鈥 the team was able to show that the cells in question are 鈥渟tuck鈥 in an activated state through changes in their DNA accessibility (epigenetics). 鈥淲e identified that we could reverse these activated cells to normal cells by treating them with particular small molecules,鈥 she said.
Walker is part of the Anseth Lab in the Department of Chemical and Biological Engineering and the Leinwand Lab in the BioFrontiers Institute and Department of Molecular, Cellular, and Developmental Biology. She said she has always been interested in heart biology and research, making this a fun project to work on.
鈥淗eart disease is the number one cause of death in developed countries, so it is amazing to me that there are still no treatments for cardiac fibrosis. I think this type of research is incredibly important for improving treatment options for people with heart disease,鈥 said.