Xiaoyun "Sean"ÌýDing
- Assistant Professor • Biomedical, Micro/Nanoscale, Thermo Fluid Sciences
- MECHANICAL ENGINEERING
Office Location:ÌýECES 158
Lab Location:ÌýECES 117
Research Interests
Biomedical microfluidics, intracellular delivery, drug delivery, lab on chip, cellular engineering
Xiaoyun Ding’s research group centers on the innovation of cutting-edge micro/nano systems for cell based biomedical applications, including micro/nano manipulation of cell and fluid, cell membrane disruption and repair, and precise intracellular/subcellular delivery. Our research is highly interdisciplinary at the frontiers of micro/nano engineering, biomedical engineering, acoustics, electronics, and other applied physics.Ìý
Ìý
Societal Impact
We strive to improve human health and life quality through innovations in engineering cell functions for cell-based immunotherapy and reducing costs of disease diagnostics and therapeutics.
Ìý
Select Publications
- GazendraÌýShakya, Tao Yang, Yu Gao,ÌýApresioÌýK.ÌýFajrial,ÌýBaowenÌýLi, Massimo Ruzzene, Mark A. Borden, and Xiaoyun Ding. Manipulating Internal Structure ofÌýEndoskeletalÌýDroplets using Acoustic Waves.ÌýNature Communication, 13 (1), 1-9, (2022).
- Yu Gao,ÌýApresioÌýKÌýFajrial, Tao Yang, Xiaoyun Ding. Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization,ÌýBiomaterials Science,Ìý9.5: 1574-1582. (2021). (BackÌýcover story)Ìý
- ApresioÌýK.ÌýFajrial,ÌýKunÌýLiu, Yu Gao,ÌýJunhaoÌýGu, RichardÌýLakerveld, and Xiaoyun Ding. Characterization of single-cell osmotic swelling dynamics for new physical biomarkers,ÌýAnalytical Chemistry, 2020. (Front cover story)
- ApresioÌýKefinÌýFajrial, QingÌýQingÌýHe, Nurul I.ÌýWirusanti, JillÌýSlansky, and Xiaoyun Ding. A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing.ÌýTheranostics, 10(12):5532-5549. (2020).
- YonghuiÌýDing, Kerri A. Ball,ÌýKristoforÌýJ. Webb, Yu Gao, Angelo D’Alessandro, William M. Old, Michael H.B. Stowell, Xiaoyun Ding. On-chipÌýAcoustoÌýThermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability,ÌýSmall, 2003506, 2020. (Front Cover Story)
- GazendraÌýShakya, Samuel E. Hoff,ÌýShiyiÌýWang, Hendrik Heinz, Xiaoyun Ding and Mark A. Borden. VaporizableendoskeletalÌýdroplets via tunable interfacial melting transitions.ÌýScience AdvancesÌý6.14: eaaz7188,Ìý(2020).
- ApresioÌýFajrial, Xiaoyun Ding, Advanced Nanostructures for Cell MembraneÌýPoration.ÌýNanotechnology, 30, 264002, (2019)
- Xiaoyun Ding, Martin Stewart,ÌýArmonÌýSharei, James Weaver, Robert Langer, andÌýKlavsÌýJensen,ÌýNature Biomedical Engineering, 1, 0039 (2017)
- Martin P Stewart,ÌýArmonÌýSharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer,ÌýKlavsÌýF Jensen,ÌýÌýNatureÌý538 (7624), 183-192 (2016)
- Xiaoyun Ding,Ìýet al.,ÌýPNAS,Ìý111, 12992-12997 (2014).
- Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 13, 3626-3649 (2013).
- Xiaoyun Ding,Ìýet al.,ÌýÌýPNAS,Ìý109, 11105-11109 (2012).
- Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 12, 4228–4231 (2012). (Cover Image)
- Xiaoyun Ding,Ìýet al.,ÌýLab on a Chip, 12, 2491-2497 (2012). (Cover image)
Ìý
Select Awards
- 2022Ìý TheÌýPenn State Graduate School Alumni Society Early Career Award (1 awardee worldwide yearly)
- 2021Ìý NIHÌýMIRA Early Stage Investigator AwardÌý
- 2021Ìý BruceÌýS. Anderson Engineering Faculty Fellow, University of ÃÛÌÇÖ±²¥Ìý
- 2020Ìý Chancellor'sÌýResearch Innovation Award, University of ÃÛÌÇÖ±²¥Ìý
- 2020Ìý LabÌýVenture Challenge 2020 winner, ÃÛÌÇÖ±²¥Ìý
- 2020Ìý BiomaterialsÌýScience Emerging Investigators 2021
- 2019Ìý W.ÌýM. Keck Foundation Medical Research Grant Award
- 2019Ìý CCTSIÌýNovel Method Development Pilot Awards, ÃÛÌÇÖ±²¥
- 2013ÌýÌýRustumÌýand Della Roy Innovation in Materials Research Award, The Penn State University
- 2013Ìý InventorÌýIncentive Award, The Penn State University
- 2013Ìý JournalÌýof Laboratory Automation Ten Breakthroughs in Innovation Award (JALA Ten 2013)
- 2012 ÌýStudentÌýPaper Competition Award, IEEE InternationalÌýUltrasonicsÌýSymposium, Dresden, GermanyÌý
- 2012 ÌýTheÌýBaxter Young Investigator Award, Chicago, USA (6 awardees nationwide)
- 2012 ÌýFirstÌýPlace Award at Penn State ESM Today Graduate Research Symposium, The Penn State University
- 2011 ÌýInnovationÌýAward at Penn State ESM Today Graduate Research Symposium, ÌýThe Penn State University